Centella asiatica (Gotu kola): Health Benefits and Side effects

Introduction

Name: Asiatic pennywort

Scientific name: Centella asiatica (L.) Urban (Syn. Centella coriacea Nannfd., Hydrocotyle asiatica L., Hydrocotyle lunataLam., and Trisanthus cochinchinensis Lour.) 

Family: Apiaceae

Common names: Gotu kola, Asiatic pennywort, Indian pennywort, Indian water navelwort, Jalbrahmi, wild violet, and tiger herb” in English.

Distribution: China, South East Asia, India, Srilanka, and Africa.

Botanical description: The plant Centella asiatica is a perennial herbaceous creeper grows mainly in moist places. Leaves are edible yellowish-green in color. The petioles of the leaves are thin and long.

Medicinal properties: The main key feature of this plant is its ability to heal wounds and enhance memory. WHO also recommends this plant for memory enhancing (1). Other important biological activities are an anti-inflammatory, antipsoriatic, antiulcer, hepatoprotective, anticonvulsant, sedative, immunostimulant, cardioprotective, antidiabetic, cytotoxic and antitumor, antiviral, antibacterial, insecticidal, antifungal, antioxidant, and for lepra, and venous deficiency treatments (2). 

Important compounds present in Centella asiatica

Asiatic acid, madecassic acid, asiaticoside, madecassoside, and madasiatic acid, betulinic acid, thankunic acid, and isothankunic acid (3,4). Triterpenes brahmic acid, centellin, centellicin, asiaticin, bayogenin, terminolic acid, centellasapogenol A, centella saponins A-D, ursolic acid, pomolic acid.

Flavonoid like quercetin, kaempferol, patuletin, rutin, apigenin, castilliferol, castillicetin, and myricetin (5,6,7). 

Polysaccharides, polyacetylenes, sterols and phenolic acids are also present in the plant.

Health benefits of Centella asiatica

1. Centella asiatica heals wound

The plant has been used traditionally in many civilizations for wound healing. Main component asiaticoside helps in increasing collagen formation and angiogenesis thus heals wound rapidly. This compounds also inhibit inflammatory and improve the capillary permeability (8)

2. Sedative properties of Centella asiatica

The plant Centella asiatica possess central nervous system effect. It has tranquilizing, rejuvenating and sedative property along with memory-enhancing capacity due to compounds brahmoside and brahminoside (8).

3. Relief from anxiety

Centella asiatica also has anxiolytic property. The components madecassoside and asiaticoside possess anxiolytic activity. These compounds help in the treatment of both acute and chronic anxiety in the pathological state (9).

4. Antidepressant properties of Centella asiatica

The triterpenes present in the plant Centella asiatica poses antidepressant effects. Studies done on the animal model suggested that the triterpene helps in creating a momentous diminution in corticosterone level and a notable increase in the amount of monoamine-related neurotransmitters (10).

5. Centella asiatica helps in the treatment of epilepsy

The extracts of Centella asiatica helps in the treatment of epileptic seizures. This is mainly because of the anticonvulsant and neuroprotective activity of the plant. Triterpenoid glycosidic compounds of Centella asiatica helps in increasing the cerebral level of GABA thus used in the treatment of epilepsy because of its anxiolytic and anticonvulsant properties (11).

6. Treats gastric ulcers

Centella asiatica extracts help in the inhibition of gastric ulcers. The plants help in protecting and strengthening the mucosal barrier of the gastric tract thus protects from oxidative damage. The anti-ulcerogenic activity of fresh juice of Centella asiatica is mainly because it increases the GABA level of the brain. Healing efficiency and anti-inflammatory efficiency of the extract also helps in protecting against ulcers (12).

7. Antidiabetic property of Centella asiatica

Centella asiatica extracts help in reducing the blood glucose level. Studies done on the animal body shows that the extract of Centella asiatica lowers the blood glucose absorption by increasing the fibrosis of islets in diabetes which also plays a vital role in the prevention of islet dysfunction (13).

8. Protects from neurodegenerative diseases

The plant Centella asiatica helps in enhancing the cognitive effects. These compounds help in repairing and restoration of damaged neurons and improve nerve impulse transmission. The main compound of Centella asiatica that repairs the brain cells are triterpene saponosides (14). Therefore the extracts of this plant help in the protection of neurological related disorders and enhance the memory.

9. Radioprotection property of Centella asiatica

Studies suggested that 100mg/Kg of body weight increases survival time and prevents the harmful effects of radiation on the body (15).

10. Centella asiatica helps in the regeneration of nervous tissue

Asiatic acid present in the leaves of Centella asiatica helps in the regeneration and enhancement of nervous tissue as per studies were done on human neuroblastoma cells (16). Therefore, enhances the learning memory.

11. Prevents Alzheimer’s disease

Alzheimer’s disease is a dementing neurodegenerative disease of old age. Oral administration of Centella asiatica extracts helps in prevention of slowing down of these diseases. The plant mainly involves reducing the oxidative stress, prevents beta-amyloid plaque formation, dopamine neurotoxicity and enzyme inhibition (17).

12. Prevents Parkinson’s disease

It is also a neurodegenerative disorder associated with degeneration of dopaminergic neurons. Studies done on animal model shows a marked decrease of degeneration of neurons due to asiaticoside dose of Centella asiatica. It protects dopaminergic neurons by opposing MPTP (1- Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and improve locomotor dysfunction (18).

Side effects of Centella asiatica

1. Take the recommended dose

Although the herbal extracts are safe to use, and Centella asiatica is full of medicinal properties and health benefits therefore also has a great demand in the market but still before taking should consider the recommended dose.

2. Skin irritation

Few cases of skin irritation and contact dermatitis were reported on taking Centella asiatica

3. Infertility in females

Studies suggested that regular consumption of Centella asiatica causes infertility in females (19). Breastfeeding mothers should also avoid taking Centella asiatica.

Dosage

600 mg of dried leaves of Centella asiatica is widely recommended. The standardized CA extract containing up to 100% total saponins (triterpenoids), 60 mg once or twice per day, are frequently used in modern herbal medicine (19).

Centella asiatica tea

This is one of the good ways to consume the leaf extracts of Gotu kola. 1 to 2 teaspoon (5-10 g) of dried leaf with hot water and honey and a steeping time of 10-15 min is suggested.

 References

  1. https://doi.org/10.1016/s0091-3057(03)00128-x
  2. https://dx.doi.org/10.1155%2F2012%2F946259
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359802/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359802/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359802/
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359802/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359802/
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116297/
  9. https://doi.org/10.1016/j.jep.2012.07.010
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359802/
  11. https://dx.doi.org/10.4103%2F0253-7613.64504
  12. https://dx.doi.org/10.4103%2F0250-474X.78519
  13. https://innovareacademics.in/journals/index.php/ajpcr/article/view/20760
  14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359802/
  15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116297/
  16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686623/
  17. https://www.hindawi.com/journals/ecam/2012/946259/
  18. https://www.ncbi.nlm.nih.gov/pubmed/20118623
  19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116297/

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